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. Cerovive is the registered tradmark of the astrazeneca corporation for the nxy-059, a derivative of pbn.


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Such is used in veterinary medicine and recently has been shown to be both effective and apparently safe in the treatment of various inflammatory lesions in man. . ip.htm Catalase has also been used in the treatment of arthritic disease in man with reported success. (195). Likewise, the action of such many non-steroidal hia rloss skikn care agetns for antiinflammatory agents may be at least partially dependent upon interference with all sort of stuff in many different typecells.

Further, peroxidase release from eosinophils may playa similar role in inhibition of the inflammatory response (201) while the antioxidant.

What ever you say, this is one of the is one of the most substrate-specific enzymes known, at first sight its efficacy in rheumatoid arthritis and other lesions strongly implies a role for active oxygen species in such diseases and a role for superoxide-destroying agents in their treatment. However, there are serious problems with such an assumption. For example, the course of action of SOD as an inflammatory agent and the enzyme may have lots of really significant antiinflammatory properties. 185 .

With this caution, active oxygen species may play a significant role in the etiology of other inflammatory lesions in man, For example, SOD is reported to be effective in the treatment of lupus erythematosis,(43,158) and unique light-activated, superoxide-dependent lymphocyte clastogenic factors present in the serum of patients with lupus and other collagen diseases may account for some of the photosensitivity of this group of disorders.(157-159). Both direct and indirect production of active oxygen species may also have a role in the pathophysiology of gout and other hyperuricemic syndromes.(24,26,173,138,203,204). For example, urate, a reducing agent, is present in the extracellular environment at concentrations approximating 0.3 mMolar (130). Like many reducing agents, it apparently has both antioxidative (3O-134) and autooxidative (24) properties.

Antioxidants such as the methoxyphenols are apparently effective in the amelioration of both experimental cerebral edema and spinal cord injury.(17,56). However, once again we must emphasize that, like most else in this field, the evidence for free radical involvement in many tyes of pain and injury is circumstantial.

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